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Only need to practice for 20 to 30 hours

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BPS Pharmacotherapy (Part1 and Part2) Sample Questions:

1. A prospective randomized study is being developed to evaluate the effects of steroids on mortality in patients who are admitted for head injury Patients will be randomly assigned to receive 48 hours of methylprednisolone or placebo. The study will have an 80% power to detect a 2% difference in mortality. Which of the following is an appropriate null hypothesis for this study?

A) Methylprednisolone reduces mortality in head injury patients.
B) Methylprednisolone and placebo are not different with respect to effect on mortality.
C) Methylprednisolone will have a 20% reduction in mortality compared with placebo.
D) Methylprednisolone will increase mortality by 2% compared with placebo.

2. Prednisone 10 mg orally daily is prescribed for a 68-year-old 60-kg patient with acute temporal arteritis. The pharmacotherapy specialist would recommend which of the following?

A) Prednisone should be discontinued after 2 Weeks.
B) Dose should be decreased to 5 mg daily.
C) Dose should be increased to 20 mg daily.
D) Dose should be increased to 60 mg daily.

3. A patient is admitted to the hospital after a motor vehicle collision. The patient takes methadone
40 mg once daily for management of an opiate addiction. The remainder of the patient's medical history is unremarkable. The medical resident caring for the patient wants to order methadone but Expresses concern related to the Substance Abuse and Mental Health Services Administration (SAMHSA) regulations.
What is the appropriate action?

A) Order morphine at equivalent dose as an alternative management.
B) Order methadone 40 mg once daily if the medical resident is a registered opioid treatment program (OTP) practitioner.
C) Order methadone 40 mg once daily if the patient shows signs of withdrawal.
D) Order methadone 40 mg once daily during inpatient treatment.

4. Using a new assay, the following readings for Drug X concentration in a blood sample are obtained: 45 ng/mL, 43 ng/mL, 45 ng/mL, 44 ng/mL, 45 ng/mL, and 45 ng/mL. The true concentration of the drug was reported as 65 ng/mL using the gold-standard assay.
On the basis of these data, the new assay should be characterized in which of the following categories?

A) Neither accurate nor precise
B) Precise but not accurate
C) Both accurate and precise
D) Accurate but not precise

5. The Randomized Aldactone Evaluation Study (RALES) yielded the following results:
* Placebo death rate: 386/841
* Spironolactone death rate: 284/822
Given these data, which of the following is the relative risk reduction for death with spironolactone, in comparison with placebo?

A) 24%
B) 11%
C) 45%
D) 31%

Solutions: